The studies of adults had mixed results, but the findings suggest that beta 2 agonists should be avoided if there is no underlying history of lung disease or evidence of wheeze or airway obstruction. 35 Two trials included children and found no benefit from albuterol in decreasing daily cough scores, daily proportion of cough, or median duration of cough, although both studies excluded children who were wheezing at the time of evaluation or had signs of bronchial obstruction. A 2015 Cochrane review does not support the routine use of beta 2 agonists for acute cough. Many patients with acute bronchitis have bronchial hyperreactivity, leading to impaired airflow in a mechanism similar to asthma. Strategies to reduce inappropriate antibiotic use include delayed prescriptions, patient education, and calling the infection a chest cold. Evaluation and treatment of bronchitis include ruling out secondary causes for cough, such as pneumonia educating patients about the natural course of the disease and recommending symptomatic treatment and avoidance of unnecessary antibiotic use. Antibiotics have been shown to provide only minimal benefit, reducing the cough or illness by about half a day, and have adverse effects, including allergic reactions, nausea and vomiting, and Clostridium difficile infection. Acute bronchitis is usually caused by viruses, and antibiotics are not indicated in patients without chronic lung disease. The cough associated with acute bronchitis typically lasts about two to three weeks, and this should be emphasized with patients. Pertussis should be suspected in patients with cough persisting for more than two weeks that is accompanied by symptoms such as paroxysmal cough, whooping cough, and post-tussive emesis, or recent pertussis exposure. Pneumonia should be suspected in patients with tachypnea, tachycardia, dyspnea, or lung findings suggestive of pneumonia, and radiography is warranted. Acute bronchitis is a clinical diagnosis characterized by cough due to acute inflammation of the trachea and large airways without evidence of pneumonia. Cough is the most common illness-related reason for ambulatory care visits in the United States.
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